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It upregulates the expression of early growth response protein 1 (EGR-1), a transcription factor that controls over 30 downstream genes involved in cytokine production, growth factor signaling, and extracellular matrix remodeling

Amer Academy Dermat Meeting, February 2002, Abstract P68, P69 ^ Finkley MB, Appa Y, Bhandarkar S

The peptide also influences pain receptors and circadian rhythms

a proportion of patients with Parkinson's disease develop dementia Cognitive impairment also occurs in the Parkinson-plus syndromes of progressive supranuclear palsy and corticobasal degeneration (and the same underlying pathology may cause the clinical syndromes of frontotemporal lobar degeneration)