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Inflammatory cytokines adversely affect different components of the central nervous system (CNS) and peripheral nervous system (PNS), which may, in turn, lead to degeneration of neurons and microglial cells, increased BBB permeability, as well as prolonged levels of microglial activation, which impairs neurogenesis (36, 37)

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The A1298C mutation is less common than the C677T mutation but has a greater impact on MTHFR activity

L.LilleyS.FoxR.CharltonH.SabaterJ.ButtonB.et al (2020)
