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There was no evidence of mutagenic potential when dihydroergotamine mesylate was tested in the presence or absence of metabolic activation in two gene mutation assays (the Ames test and the in vitro mammalian Chinese hamster V79/HGPRT assay) and in an assay for DNA damage (the rat hepatocyte unscheduled DNA synthesis test)

Avoid vigorous shaking or vortexing

Charlson ME, Pompei P, Ales KL, MacKenzie CR

According to NICE guideline NG198 on acne management, first-line options include fixed-combination topical treatments such as adapalene with benzoyl peroxide or benzoyl peroxide with clindamycin
