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The therapy implies the full injury course, for both acute and prolonged periods, early and delayed application (i.e., at 1 min, 15 min, 24 h or 48 h ligation-time)

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BPC-157 upregulates survival genes (Akt1, KRAS, Src, Foxo1), reduces inflammatory mediators (IL-6, TNF-, NOS2, NFB), scavenges reactive oxygen species through its four carboxylic groups, activates vascular bypass pathways, and maintains blood flow despite vessel occlusion

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