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Thermoregulatory Control Thermoregulatory control in humans is often studied by considering changes in thermoeffector output relative to changes in skin and/or deep body temperatures
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Some patients may require injections more frequently, and if a true deficiency is identified, several injections over 1-2 weeks are needed, known as a loading dose

Their prescription allows for their use as potent analgesics in severe acute pain therapy (intraoperative and postoperative analgesia), even by infusion, but only in specific conditions, such as in monitored patients in the intensive care units, especially in mechanically ventilated subjects [65]
