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For instance, in the past decades we have seen the optimum level for vitamin D increase, as we have more evidence that lower levels of vitamin D are associated with disease in the long term (e.g

353,354,355 Traditionally, citrate is oxidized in the tricarboxylic acid (TCA) cycle, while high cellular zinc levels in normal prostate cells prevent this process by inhibiting the activity of mitochondrial aconitase (m-aconitase) 356 (Fig

DSouza GG, Rammohan R, Cheng SM, et al

SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024