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Thymosin alpha-1, for example, can both stimulate and regulate immune function depending on context
In addition to lysosomal changes, we also identified UPS system alterations in our enrichment pathway analysis, consistent with the increase in aggregated protein inclusions and the sensitivity of the DJ1 mutation cell lines to proteasome inhibition
In that sense, in silico modeling and molecular dynamics (MD) simulations showed structural changes in the -SNAP M105I mutant protein and the conceals of the hydrophobic amino acids of the N-terminal loop
203210, pubmed.ncbi.nlm.nih.gov/23892832/
