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In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)
In all, the exact mechanisms by which insulin suppresses adipocyte lipolysis are currently not completely understood
NAD+, on the other hand, is a critical coenzyme involved in DNA repair, energy production, and cellular health
1 Comment Like Comment Grant Pagdin MD 1w Report this comment Thanks for this, Chris
