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The original goal of the staple was to get the peptide into the cell, but it turns out the staple can also enhance the binding and enhance the specificity, Keating says
They completely transform the compounds behavior in the body
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This established that the peptide is not limited to local gastrointestinal action but reaches systemic circulation at biologically active concentrations after oral dosing a critical distinction for researchers designing protocols targeting non-GI tissue pathways
