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MedComm (2024) 5(9):e693

These key mediators can activate signal transduction cascades as well as induce changes in transcription factors, such as nuclear factor kappa B (NF-B), signal transducer and activator of transcription 3 (STAT3), hypoxia-inducible factor-1 (HIF1-), activator protein-1 (AP-1), nuclear factor of activated T cells (NFAT) and NF-E2 related factor-2 (Nrf2), which mediate immediate cellular stress responses (Figure 2)

This comprehensive formula packed with premium B vitamins including folate (5-Methyltetrahydrofolate), B6 (Pyridoxal 5-phosphate), B12 (methylcobalamin), B2 (Riboflavin 5 phosphate), and anhydrous betaine (trimethylglycine)

This is different from water retention, which is more of a puffy, swollen feeling around the abdomen AND other parts of the body