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Accumulation of ROS can activate the mitochondrial apoptotic pathway and induce apoptosis, and esculetin can block this process by scavenging ROS (32)
In Encyclopedia of Stress (pp

Enhances skin texture, elasticity, and wound healing

Iron exhibits redox activity and engages in the production of intracellular free radicals and lipid peroxides ( via the Fenton reaction, which means reactions of Fe 2+ and peroxides to generate oxygen-centered radicals (Winterbourn, 1995)