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Acetaldehyde is a strong electrophilic compound produced endogenously as the initial intermediate in oxidative ethanol metabolism

M., Sanders L., et al

The abnormal processing of sensory inputs in the CNS [68]

Iron overload enhances oxidative stress and the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome signaling, triggering the evolution of several inflammatory mediators, resulting in a cascade of inflammatory responses and renal dysfunction in iron-overloaded rats (Kernan and Carcillo, 2017)
