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The thyroid gland absorbs iodine from the blood and incorporates it into thyroid hormones
Ob-Rb receptor activation on monocytes and macrophages initiates critical signaling pathways, encompassing JAK/STAT, MAPK, and PI3K/Akt [94,95,96,97,98]

In the case of IL-4, downstream signaling leads to the activation of the peroxisome proliferator-activated receptor gamma (PPAR) transcription factor (Guo et al., 2022)
10.1016/j.bbrc.2010.05.108 Biochem
