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The clinical efficacy of MPH is based on its mechanism of action, which involves the inhibition of DAT and NET

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Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP

Similarly, significant protein carbonyl accumulation was observed in ARPE-19 cells (derived from human RPE cells) following blue light exposure (430 nm, 1.5 mW/cm 2 , 20 min) in the presence of accumulated A2E, with protein carbonyl levels increasing by up to several dozen times relative to nonirradiated controls 165