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It is a 16-amino acid peptide that activates AMPK, the master metabolic regulator, by inhibiting the folate cycle and accumulating AICAR, a potent endogenous AMPK activator

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It also aligns with epidemiological observations that folate supplementation around conception reduces neural tube defectsa clear demonstration of gene-nutrient interaction in neurodevelopmentand invites inquiry into whether similar principles apply to ASD (though the ASD relationship is undoubtedly more complex and multifactorial)