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We hope this gives some insight into the problematic nature of pinpointing cause and effect within the constraints of such a complex environment
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SIRT3, SIRT4, and SIRT5 are mitochondrial and can shuttle to the nucleus ( The enzymatic activity of SIRTs is dependent on NAD + as a cofactor and plays an important role in controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis
