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The MMACHC encoded protein dealkylates both adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl) and also decyanates cyanocobalamin (CN-Cbl)

They observed significantly high arteriolar dilation and increased capillary perfusion in the treatment group with 100mg/kg NAC, which led to reduced ischemia and apoptotic cell death in all areas of the flap

GPX4 depletion in mouse embryonic fibroblasts and in neurons causes lipid peroxidation and AIFM1/AIF (apoptosis-inducing factor, mitochondrion-associated 1)-mediated and caspase-independent apoptosis [20]

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