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Ferroptosis plays a crucial role in the pathological progression of osteosarcoma, and agents such as bavachin, TPZ, cisplatin, PEITC, and EF24 induce ferroptosis in osteosarcoma cells, thereby exerting therapeutic effects ( Table 1 )

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However, when glucose is deficient, the insufficient supply of NADPH leads to the inability to timely maintenance of redox homeostasis, resulting in the abnormal accumulation of disulfides (such as cystine) within cells, which triggers a stress response

doi: 10.1016/j.brainresrev.2008.03.002 [DOI] [PubMed] [Google Scholar] 119.Xu B, Wang Z, Li G, Li B, Lin H, Zheng R, et al
