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Taken together, it appears that the increased flux of glucose through the polyol pathway can lead to oxidative stress and protein glycation via a variety of pathways, and that the contributions of these pathways to diabetic cataractogenesis are influenced by species differences in the relative activity of polyol pathway enzymes to favour either sorbitol formation (osmotic stressor) or fructose formation (oxidative stressors)

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Open field test (OFT) The OFT can provide quantitative measurements of animal locomotory and exploratory behavior

It slows gastric emptying, tempers the post-meal glucagon spike, and flips satiety switches in the hindbrain and hypothalamus