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Interestingly, we found that a surface-exposed cysteine residue (Cys 63 ) located in the thioredoxin domain of Ec CnoX, away from the SXXC motif, is involved in the formation of mixed-disulfide complexes with substrate proteins under HOCl stress (more than 130 proteins were identified), thereby protecting them from irreversible damage which could otherwise block reactivation (Goemans et al., 2018b)

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461 Two phase III trials (NCT03444870 and NCT03443973) were recently terminated

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