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Some practitioners employ intermediate dose increases, such as escalating by 0.25 mg increments rather than doubling doses, to improve tolerance in sensitive patients

ONeill, J

The GLP1R rs6923761 genetic variant, measured by PlexusDx's Precision Peptide Genetic Test, predicts differential responsiveness to semaglutide's appetite-suppressing effects

Morello et al., 2018), emphasizing the need for additional studies