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(3) Organ-centric reductionism: the current investigations predominantly focus on isolated organ systems, neglecting BBRs pleiotropic effects within inter-organ communication networks critical to systemic metabolic regulation

Immune System Support Research suggests that maintaining adequate levels of glutathione can bolster immune function, helping the body to fend off infections and other illnesses

Finally, targeted modulation of NFB and STAT3 pathways may offer selective protection against neuro-inflammation in dementia, for example using natural and rationally-designed inhibitors of the NFB pathway (as reviewed, Srinivasan and Lahiri, 2015) and small molecule STAT3 inhibitors which are effective in cancer models (Fletcher et al., 2011)

Interestingly, Canals and Clarke (2022) found that mRNA expression levels of CerS do not directly correlate with the concentrations of ceramides with specific chain lengths