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At the chemical level the oxido-reductive (redox) status of a biological system can be quantitatively expressed through the relative levels of some biological indicators such as soluble thiols, nucleotide cofactors and other molecules which coexist in the organism as the pair of their reduced and oxidized form

The activity of these enzymes is regulated by many pathways, suggesting that the synthesis of GSH must respond to a multitude of environmental conditions

Furthermore, together these data support that (1) while both Dkk2 and Notum may participate in regulating the initiation of catagen, they are not required to induce catagen