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There are three activities of the MTHFD1 encoded enzyme that include, N 5 , N 10 -methenyl-THF (5,10-methenyl-THF) cyclohydrolase, 5,10-methylene-THF dehydrogenase, and 10-formyl-THF synthetase

Chang Y, Ganesh T, Horton JR, Spannhoff A, Liu J, Sun A, et al

GR often plays an important role in the protection of plants from temperature stresses by preventing the oxidation of enzymes and membranes 42