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These microbial products may work as antigens or molecular patterns that prime or stimulate arthritogenic immune cells which recirculate from the gut to the synovial joints triggering the onset of arthritis or fueling an already established synovial inflammation [4]

However, our deepening understanding of the contribution of Fc-dependent effector functions to the protection mediated by vaccines and monoclonal antibodies warrants the development and validation of standardized assays to account for these functions and to assess their contribution to immunity and their possible use as correlates of protection (Box 2)
