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Conditions affecting the small intestine, such as malabsorption syndromes (celiac disease and tropical sprue), may also result in vitamin B 12 deficiency

\ In the absence of coenzyme B)Tj /T1_2 8 Tf 410.74 -1.8 Td (12)Tj /T1_2 10 Tf 8 1.8 Td (, tetrahydrofolate cannot be)Tj -418.74 -13.366 Td (regenerated from its inactive storage form, 5-methyltetrahydrofolate, an\ d a functional folate deficiency occurs
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A study from 2009 found that 22 percent of type 2 diabetes patients also had less of this vitamin than they needed and that the use of metformin may have been involved
