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Considerably for each of the different interstitial lung diseases outcomes varies

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123,124,125,126 Interestingly, although IGF-IR has no nuclear localization sequence and is normally localized to the cytoplasmic membrane, it can undergo nuclear ectoposition by SUMOylation, binding to promoter DNA of its own gene and some oncogene-related genes, such as JUN and FAM21, to promote gene expression