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Within the ER (endoplasmic reticulum), there are processes that check to make sure that proteins are made and folded correctly

The high failure rates of experimental drugs in late-stage clinical trials highlight a disconnect between preclinical findings and human studies, largely due to inadequate disease models that fail to capture the full complexity of human AD pathology ( in vitro and in vivo studies showing their efficacy in reducing oxidative stress, neuroinflammation, and A accumulation (Mohamed Yusof and Mohd Fauzi 2024)

[DOI] [PMC free article] [PubMed] [Google Scholar] 136.Xiang C, Yan HC

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