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Because metabolic remodeling is a hallmark of HF (Ingwall, 2009) and atrial fibrillation (Harada et al., 2017) it is pertinent to determine if insulin resistance and diabetes alters how LCACs are handled in these hearts and whether this cardio-metabolic interaction drives disease phenotype

Finally, the use of the Generalized Linear Mixed Model (GLMM) in our study allowed for a more comprehensive data analysis, considering additional covariates and their potential interactions throughout the treatment