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To address potential off-target complement activation in vivo, NIP specific IgG1 WT, REW and RGY were administered to Tg32 mice before collection of plasma after 24 h (Fig

Interestingly, the common findings from these studies demonstrated a high sensitivity of the spleen with respect to LDR-induced effects that are not similar to those found in other tissues, such as brain, liver, lung, and testis

Notably, indoleamine 2,3-dioxygenase 1 (IDO1), a pivotal enzyme in tryptophan catabolism, drives immunosuppression by converting tryptophan to kynurenine (Kyn), thereby activating the aryl hydrocarbon receptor (AhR)

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