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Lancet Respir Med 2015

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proinflammatory cytokines such as IL-6, tumor necrosis factor (TNF-), and interleukin-1 (IL-1)

Chronic inflammation can lead to a variety of problems in the skin, such as decreased skin barrier function, diminished cell regeneration, and decreased wound healing ( 4.3.1 Anti-glycation effects Glycation and the accompanying accumulation of skin advanced glycation end products (AGEs) have been implicated in skin research as one of the mechanisms leading to skin aging ( in vivo and avoiding the accumulation of AGEs ( in vitro glycosylation study ( 4.3.2 Phenolic metabolites modulate inflammatory responses Phenolic metabolites found in plant bioactive metabolites have been shown to modulate inflammatory responses, protect skin cells from damage and promote a healthier appearance ( In vitro studies using cell lines such as RAW 264.7 macrophages have shown that phenolic metabolites in plant bioactive metabolites significantly reduce the production of inflammatory cytokines and mediators when stimulated by lipopolysaccharide (LPS), a common inflammatory trigger ( One of the key mechanisms by which phenolic metabolites exert their anti-inflammatory effects is through the inhibition of pro-inflammatory mediator production