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Meanwhile, tryptophan 2,3-dioxygenase (TDO2), the rate-limiting enzyme of the kynurenine pathway, was found to be upregulated in ovarian cancer tissues, which promotes tumor cell proliferation, migration and invasion (113)
114,220,223,224,225 Different CBS inhibitors have been designed and tested over the past years, starting with amino-oxyacetic acid (AOAA) 52,58,60 and related prodrugs
K., Qureshi S
(2018) 19:e295304
