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Description
This is the first demonstration that an extracellular nutrient, methionine, can supplant the need for intracellular use of NADPH by GR or TrxR1 and sustain cytosolic redox homeostasis in mammalian cells
In addition, P-gp has also been reported to pump irinotecan and metabolites out of the cells (Trumpi et al., 2015)
The predominant effect is inhibition of NF-B, a central inflammatory hub
They can also be utilized as common dietary additives, like food coloring
