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doi: 10.3389/fncel.2013.00090 Received 11 April 2013 Accepted 22 May 2013 Published 11 June 2013 Volume 7 - 2013 Edited by Chao Deng, University of Wollongong, Australia Reviewed by T

It is well known in fact that malignant tumours microenvironment is acidic and alkalinisation of tumour microenvironment highly impair tumour growth and progression 24 , 25

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