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Simply mix the ampoule contents with the vial, add 5ml of sterile water, and it's ready for either a direct IV line or butterfly syringe injection
Paclitaxel can also disrupt intracellular calcium homeostasis by enhancing the interaction between the neuronal calcium sensor-1 protein and inositol-1,4,5-trisphosphate receptor, leading to calcium overload and triggering neuronal cell death pathways, including calpain and caspase 3/7
Although it plays a minor role, transsulfuration contributes to de novo cysteine synthesis from methionine which is recognized as an additional mechanism for maintaining cysteine pools in the tumor microenvironment (49)
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