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Furthermore, the mutator phenotype associated with defective MutL activity was suppressed when a non-functional recB allele, derived from ET-37 meningococcal strains, replaced the functional recB allele, suggesting that in MutL-deficient strains, hypermutation mostly arises during post-replicative DNA synthesis associated with the activity of the RecBCD recombination pathway (Colicchio et al., 2006a)

Gene expression profiles Rank regression analysis was used to correlate change in baseline gene expression with 1-month IGF-I (Figure 1)

Researchers should note that more investigation is needed to fully comprehend this peptides mechanisms and effects