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Risk factors in autism: Thinking outside the brain

Inhibition of cholesterol esterification, either by genetic ablation or by pharmacological inhibition of sterol O-acyltransferase 1 (SOAT1) (with avasimibe in micromolar doses), enhances the effector functions and proliferation of CD8 + T cells without affecting CD4 + T cells

Takeaway: An area of interest for age-related immune decline

Genes involved in lipid metabolism, collagen synthesis, extracellular matrix organization, and receptor-mediated endocytosis are also associated with AMD (15)
