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Cancer cells may metabolize glutamate to -ketoglutarate through one of two different pathways (glutamate dehydrogenase or aminotransferases), with aminotransferases potentially supporting a more biosynthetic and pro-growth phenotype

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Regarding cisplatin-induced ototoxicity, recent studies have also confirmed that benzamil exhibits significant protective effects on cochlear explant hair cells against cisplatin toxicity [58]

CO also suppressed the function of early growth response protein 1 (EGR-1), a crucial transcription factor in the inflammatory response initiated by macrophages [60]