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The poor prognosis and high susceptibility to recurrence in patients with tumors such as HGSOC can be attributed to the genetic instability of these tumors
In this sense, PACAP has been postulated as the GHRH ancestor in less evolved vertebrates (50, 170, 173)

HIF-1 activates human intestinal trefoil factor (ITF) [112]
[DOI] [PMC free article] [PubMed] [Google Scholar] [6].Gergely PJ, Grossman C, Niland B, et al
