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It is noteworthy that a decrease in DNA hydroxymethylation has been observed in cancer cells and tumors (Haffner et al., 2011
Studies have shown that TT supplementation increases skeletal mRNA expression of -catenin, the central transcription factor in the Wnt pathway, in orchidectomized rats ( In vitro studies using pre-osteoblasts have shown that -TT suppresses critical signaling molecules in the Wnt pathway, stimulating cell proliferation and differentiation (53)
Nat Commun 8:2053 Xie L, Ushmorov A, Leith F, Guan H, Steidl C, F J, Pelzer C, Vogel MJ, Maier HJ, Gascoyne RD, Mller P, Wirth T (2012) FOXO1 is a tumor suppressor in classical Hodgkin lymphoma
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