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Second, the oxidative stress mechanism

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reported that PMX53, a C5a receptor 1 (C5aR-1) antagonist, mitigated hepatic IRI through inhibiting pro-inflammatory cytokine release and neutrophil/macrophage infiltration and platelet aggregation (Kusakabe et al., 2020), suggesting the crosstalk between coagulation and complement system

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Peer review Peer review information Nature Reviews Bioengineering thanks Chao Wang, Walter Storkus, Betty Kim and Benjamin Schrank for their contribution to the peer review of this work

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