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The rd1 mouse is a common animal model used to study RP in which the expression of over 60 genes, related to proliferation, apoptosis, and transcription, is modified via a mutation in the phosphodiesterase-6 gene, which affects the metabolism of cyclic guanosine monophosphate
J Neurosci 36(8):23832390
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Because chronic inflammation is strongly associated with metabolic dysfunction, this mechanism has generated interest among researchers studying metabolic disease
