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Moreover, a study (43) has reported bone loss in antibiotic-pretreated mice 1 week after receiving fecal bacteria from mice with glucocorticoid-induced osteoporosis, somewhat corroborating the endocrine involvement of FMT in influencing bone health
Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice
However, in the SW620/Ad300 (P-gp-overexpressing) and S1-M1-80 (ABCG2-overexpressing) colon cancer xenograft models, the combination of regorafenib and paclitaxel or the combination of regorafenib and topotecan resulted in a synergistic antitumor effect which demonstrated that regorafenib overcame the resistance of paclitaxel to P-gp-overexpressing SW620/Ad300 tumors and the resistance of topotecan to ABCG2-overexpressing S1-M1-80 tumors in mice (Wang et al., 2017b
The protocols differ in important ways, and understanding those differences is essential for anyone planning a research protocol
