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The TMZ-resistant glioma cells have elevated ROS and DMT1 expressions, compared to sensitive cells, implying decreased GPX4 levels inside cells and occurrence of ferroptosis ( 3.1.5 Oxaliplatin Oxaliplatin enters tumor cells via copper transporter 1 (CTR1), where it goes through the activation step of chlorine ligand substitution, usually replaced by water molecules or other small molecules containing sulfhydryl groups

Future research should explore combination strategies of this drug with other therapies to maximize its therapeutic value

doi: 10.1016/j.onano.2025.100243 [DOI] [Google Scholar] 79.Alam MI, Baboota S, Ahuja A, Ali M, Ali J, Sahni JK

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