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After 72 h, the sites of the brown area were assessed using a chromameter (CR-400, Konica Minolta, Japan), and the degree of discoloration with the sample applied twice a day was measured every day

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Acetyl-l-carnitine-induced analgesia in neuropathic and inflammatory pain is long-lasting, and its duration goes beyond the time of active treatment [34, 35]

This rather substantial rise in level suggests that the D-Carnitine in sample solution may be less stable than the reference solution when stored at room temperature
