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doi: 10.1002/aur.1686 132 MaierSDppersALRungeKDackoMLangeTFangmeierTet al
So the typical pattern is a short loading phase of weekly shots to refill the tank, followed by a maintenance injection every few weeks to a month to keep levels steady
Arafat R, Khan S, Naveed S
The data on safety are available, but scarce
