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(4) availability of extractable quantitative data (means SD, OR/HR with 95% CI, or -coefficients)

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Acetazolamide (brand names: Diamox) is a diuretic and antiglaucoma agent, used primarily to treat glaucoma (increased eye pressure), syringomyelia (cyst that affects nervous system), and metabolic alkalosis

Although SLNs and NLCs have proven to be potential candidates for the treatment of AD, as evidenced by their effectiveness in both hydrophilic and hydrophobic therapeutic agent transportation across the BBB (Dighe et al., 2023), NLCs have more recently emerged as the dominant platforms for an alternative intranasal administrationnose-to-brain delivery (Shehata et al., 2023b,a