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The therapeutic potential for GGC to increase GSH is related to the second GSH biosynthetic enzyme, glutathione synthetase (GS) which is not regulated by non-allosteric feedback inhibition by GSH
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Notably, ferroptotic cell death, regardless the mechanisms of activation, can be blocked by iron chelators, indicating a central role of iron in the regulation and execution of ferroptosis
[DOI] [PubMed] [Google Scholar] 56.Pierson H et al
