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Metabolic's parent company, Calzada Ltd, has had to deny it was involved in a secret drug trial involving four Essendon players and claims the case notes, from Dank, were to support a patent application and not for any use in a clinical trial

In recent years, its also gained attention as part of medical weight loss programs

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It does not cause photosensitivity (unlike retinoids), does not thin the skin (unlike corticosteroids), and does not require a tolerance-building period
