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The mechanism of ATRAs inductive effect on GS expression required ERK1/2 signaling but the mechanism is not clear, as ATRA treatment did not influence the expression of Nrf2 or NFB and it had no effect on the GS promoter activity [141]
Neuron 96 , 651666 (2017)
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There was also no difference in adverse effects reported and no reports of ovarian hyper-stimulation syndrome, a potentially life-threatening condition associated with drugs stimulating ovulation
